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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
07/06/2022 |
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Actualizado : |
30/11/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
MACHADO, M.; CASTRO, M.B.; WILSON, T. M.; GONÇALVES , A. A. B.; PORTIANSKY, E.; RIET-CORREA, F.; BARROS, S. S. |
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Afiliación : |
MIZAEL MACHADO DA COSTA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MÁRCIO B. CASTRO, University of Brasilia, Brasília, Brazil; TAIS M. WILSON, University of Brasilia, Brasília, Brazil; ALEXANDRA A. B. GONÇALVES, University of Brasilia, Brasília, Brazil; ENRIQUE L. PORTIANSKY, National University of La Plata, La Plata, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Federal University of Bahia, Salvador, Brazil; SEVERO S. BARROS, Federal University of Santa Maria, Rio Grande do Sul, Brazil. |
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Título : |
Poisoning by Nierembergia veitchii: Effects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Veterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430 |
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ISSN : |
0300-9858 |
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DOI : |
10.1177/03009858221098430 |
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Idioma : |
Inglés |
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Notas : |
Article history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay. |
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Contenido : |
ABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022. MenosABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It ... Presentar Todo |
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Palabras claves : |
Arterial mineralization; Arteries; Enzootic calcinosis; Exosomes; Pathogenesis; PLATAFORMA DE SALUD ANIMAL; Toxicity; Vascular smooth muscle cells. |
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Asunto categoría : |
L50 Fisiología y bioquímica animal |
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Marc : |
LEADER 03391nam a2200313 a 4500
001 1063233
005 2022-11-30
008 2022 bl uuuu u01u1 u #d
022 $a0300-9858
024 7 $a10.1177/03009858221098430$2DOI
100 1 $aMACHADO, M.
245 $aPoisoning by Nierembergia veitchii$bEffects on vascular smooth muscle cells in the pathogenesis of enzootic calcinosis.$h[electronic resource]
260 $aVeterinary Pathology, 2022, Volume 59, Issue 5, pages 814-823. doi: https://doi.org/10.1177/03009858221098430$c1177
500 $aArticle history: Article first published online May 19, 2022; Published online September 2022. -- Corresponding Author: Franklin Riet-Correa, Postgraduate Program in Animal Science in the Tropics, School of Veterinary Medicine and Animal Science, Federal University of Bahia, Salvador, Bahia 40170-110, Brazil. Email: franklinrietcorrea@gmail.com -- This work was funded by National Institute of Agricultural Research (INIA) of Uruguay (Project CL 44), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil, (Finance Code 001) and National University of La Plata (Project V270). A postgraduate scholarship was provided to Mizael Machado by INIA, Uruguay.
520 $aABSTRACT - Vascular mineralization is a hallmark of enzootic calcinosis. Histopathological, ultrastructural, and immunohistochemical investigations were performed on the external carotid arteries of seven sheep naturally poisoned by Nierembergia veitchii. Histologically, moderate to marked hyperplasia of the tunica intima was observed without mineralization. The tunica media exhibited mild to severe mineralization and osteochondroid metaplasia. Sheep with enzootic calcinosis showed arterial overexpression of osteopontin and tissue-nonspecific alkaline phosphatase and immunolabeling for osteonectin and osteocalcin in both intima and media layers of the tested arteries. The main ultrastructural finding in the tunica media was a marked phenotypic change of vascular smooth muscle cells from a contractile phenotype (VSMC-C) into a synthetic phenotype (VSMC-S). In the tunica media, VSMC-S produced matrix and extracellular vesicles, forming mineralizable granules associated with arterial mineralization. VSMC-S were also present in the tunica intima, but matrix and extracellular vesicles and mineralization were not observed. The absence of matrix and extracellular vesicles in the intimal hyperplasia, even in the presence of noncollagenous bone proteins, tissue-nonspecific alkaline phosphatase, and vitamin D receptors, reinforces the hypothesis that the presence of matrix and extracellular vesicles are crucial for the development of vascular mineralization in enzootic calcinosis. It is proposed that the two different VSMC-S phenotypes in calcinosis are due to the expression of at least two genetically different types of these cells induced by the action of 1,25(OH)2D3. © The Author(s) 2022.
653 $aArterial mineralization
653 $aArteries
653 $aEnzootic calcinosis
653 $aExosomes
653 $aPathogenesis
653 $aPLATAFORMA DE SALUD ANIMAL
653 $aToxicity
653 $aVascular smooth muscle cells
700 1 $aCASTRO, M.B.
700 1 $aWILSON, T. M.
700 1 $aGONÇALVES , A. A. B.
700 1 $aPORTIANSKY, E.
700 1 $aRIET-CORREA, F.
700 1 $aBARROS, S. S.
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INIA Las Brujas (LB) |
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha actual : |
28/11/2019 |
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Actualizado : |
05/09/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
LAMPERT, V.D.N.; CANOZZI, M.E.A.; MCMANUS, C.M.; DILL, M.D.; OLIVEIRA, T.E.D; MERCIO, T.Z.; TEIXEIRA, O.D.S.; BARCELLOS, J.O.J. |
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Afiliación : |
VINÍCIUS DO NASCIMENTO LAMPERT, Embrapa Pecuária Sul, Rod. BR 153, km 603 , 96401-970, Bagé, RS, Brasil.; MARÍA EUGENIA ANDRIGHETTO CANOZZI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CONCEPTA MARGARET MCMANUS, Universidade de Brasília, Campus Universitário Darcy Ribeiro,70910-900,Brasília, DF, Brasil.; MATHEUS DHEIN DILL, Universidade Federal do Rio Grande do Sul, Campus Litoral Norte, Depto. Interdisciplinar, Brasil.; TAMARA ESTEVES DE OLIVEIRA, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 7712, Alegre, RS, Brasil.; THOMAZ ZARA MERCIO, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 7712, Alegre, RS, Brasil.; ODILENE DE SOUZA TEIXEIRA, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 7712, Alegre, RS, Brasil.; JÚLIO OTÁVIO JARDIM BARCELLOS, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 7712, Alegre, RS, Brasil. |
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Título : |
Modelling beef cattle production systems from the pampas in brazil to assess intensification options. |
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Fecha de publicación : |
2020 |
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Fuente / Imprenta : |
Scientia Agricola, 2020, Volume 77, Issue 4, Article number e20180263. OPEN ACCESS. DOI: http://dx.doi.org/10.1590/1678-992x-2018-0263. |
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ISSN : |
1678-992X |
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DOI : |
10.1590/1678-992x-2018-0263 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received August 08, 2018 /Accepted January 18, 2019. Corresponding author (julio.barcellos@ufrgs.br). Acknowledgments:
To the Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ? Programa Nacional de Pós-Doutorado (PNPD) (Project - 2842/2017). Authors? Contributions: Conceptualization: Lampert, V.N.; Barcellos, J.O.J. Data acquisition: Lampert, V.N.; Barcellos, J.O.J. Data analysis: Lampert, V.N.; Barcellos, J.O.J.; Mercio, T.Z.; Mcmanus, C.M.; Dill, M.D. Design of methodology:Lampert, V.N.; Barcellos, J.O.J. Writing and editing:Lampert, V.N.; Barcellos, J.OJ.; Teixeira, O.S.; Oliveira,T.E.; Canozzi, M.E.A. |
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Contenido : |
ABSTRACT: Traditional livestock productivity is hard to estimate, since it depends on a gamut of animal production indicators that are difficult to measure for many farms. Thus, we propose an analytical method for estimating productivity and understanding the importance of animal production indicators under different full-cycle cattle production systems in Brazil. To evaluate the impact of these indicators, equations were derived from a comutational model of herd evolution for estimating the output parameters of the system as follows: productivity per hectare (PH) and offtake rate (COR), as a function of the indicators; calving rate (CR), mating age (AM), age of slaughter (AS) and stocking rate (SR). For this analysis, twenty-seven scenarios (simulation data) of low to high productivity were used, resulting from the combination of the following factors and levels: 1) calving rate of 50, 65 and 80 %; 2) mating age of heifers of one, two and three, years of age; and 3) age at slaughter of one, two and three year old steers. The scenario with the highest impact for each parameter and the indicator of highest impact for each scenario were identified for the production conditions in the region. Under most scenarios, a reduction in mating age had a greater impact on the productivity indexes compared to a reduction in slaughter age. Appropriate management of available technologies enables farmers to compare the marginal impacts of specific indicators on full-cycle production systems for beef cattle. MenosABSTRACT: Traditional livestock productivity is hard to estimate, since it depends on a gamut of animal production indicators that are difficult to measure for many farms. Thus, we propose an analytical method for estimating productivity and understanding the importance of animal production indicators under different full-cycle cattle production systems in Brazil. To evaluate the impact of these indicators, equations were derived from a comutational model of herd evolution for estimating the output parameters of the system as follows: productivity per hectare (PH) and offtake rate (COR), as a function of the indicators; calving rate (CR), mating age (AM), age of slaughter (AS) and stocking rate (SR). For this analysis, twenty-seven scenarios (simulation data) of low to high productivity were used, resulting from the combination of the following factors and levels: 1) calving rate of 50, 65 and 80 %; 2) mating age of heifers of one, two and three, years of age; and 3) age at slaughter of one, two and three year old steers. The scenario with the highest impact for each parameter and the indicator of highest impact for each scenario were identified for the production conditions in the region. Under most scenarios, a reduction in mating age had a greater impact on the productivity indexes compared to a reduction in slaughter age. Appropriate management of available technologies enables farmers to compare the marginal impacts of specific indicators on full-cycle production system... Presentar Todo |
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Palabras claves : |
ADOPTION OF TECHNOLOGY; ANIMAL PRODUCTION; MANAGEMENT; STOCKING RATE. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/16696/1/Scientia-Agricola-2020.pdf
https://www.scielo.br/pdf/sa/v77n4/1678-992X-sa-77-04-e20180263.pdf
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Marc : |
LEADER 03289naa a2200289 a 4500
001 1060474
005 2022-09-05
008 2020 bl uuuu u00u1 u #d
022 $a1678-992X
024 7 $a10.1590/1678-992x-2018-0263$2DOI
100 1 $aLAMPERT, V.D.N.
245 $aModelling beef cattle production systems from the pampas in brazil to assess intensification options.$h[electronic resource]
260 $c2020
500 $aArticle history: Received August 08, 2018 /Accepted January 18, 2019. Corresponding author (julio.barcellos@ufrgs.br). Acknowledgments: To the Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) ? Programa Nacional de Pós-Doutorado (PNPD) (Project - 2842/2017). Authors? Contributions: Conceptualization: Lampert, V.N.; Barcellos, J.O.J. Data acquisition: Lampert, V.N.; Barcellos, J.O.J. Data analysis: Lampert, V.N.; Barcellos, J.O.J.; Mercio, T.Z.; Mcmanus, C.M.; Dill, M.D. Design of methodology:Lampert, V.N.; Barcellos, J.O.J. Writing and editing:Lampert, V.N.; Barcellos, J.OJ.; Teixeira, O.S.; Oliveira,T.E.; Canozzi, M.E.A.
520 $aABSTRACT: Traditional livestock productivity is hard to estimate, since it depends on a gamut of animal production indicators that are difficult to measure for many farms. Thus, we propose an analytical method for estimating productivity and understanding the importance of animal production indicators under different full-cycle cattle production systems in Brazil. To evaluate the impact of these indicators, equations were derived from a comutational model of herd evolution for estimating the output parameters of the system as follows: productivity per hectare (PH) and offtake rate (COR), as a function of the indicators; calving rate (CR), mating age (AM), age of slaughter (AS) and stocking rate (SR). For this analysis, twenty-seven scenarios (simulation data) of low to high productivity were used, resulting from the combination of the following factors and levels: 1) calving rate of 50, 65 and 80 %; 2) mating age of heifers of one, two and three, years of age; and 3) age at slaughter of one, two and three year old steers. The scenario with the highest impact for each parameter and the indicator of highest impact for each scenario were identified for the production conditions in the region. Under most scenarios, a reduction in mating age had a greater impact on the productivity indexes compared to a reduction in slaughter age. Appropriate management of available technologies enables farmers to compare the marginal impacts of specific indicators on full-cycle production systems for beef cattle.
653 $aADOPTION OF TECHNOLOGY
653 $aANIMAL PRODUCTION
653 $aMANAGEMENT
653 $aSTOCKING RATE
700 1 $aCANOZZI, M.E.A.
700 1 $aMCMANUS, C.M.
700 1 $aDILL, M.D.
700 1 $aOLIVEIRA, T.E.D
700 1 $aMERCIO, T.Z.
700 1 $aTEIXEIRA, O.D.S.
700 1 $aBARCELLOS, J.O.J.
773 $tScientia Agricola, 2020, Volume 77, Issue 4, Article number e20180263. OPEN ACCESS. DOI: http://dx.doi.org/10.1590/1678-992x-2018-0263.
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